Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 10/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HAO2 | Q9NYQ3 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2802546 | 0.86 | MYC (0.53) | MYCNR4A1KDM4EALDH1A1MAPT | |
| SCHEMBL956958 | 0.77 | CNR1 (0.47) | KDM4EALDH1A1LMNAMAPTALOX15 | |
| SCHEMBL4343632 | 0.73 | LRRK2 (0.36) | ALDH1A1HAO2 | |
| SCHEMBL3937442 | 0.68 | CFTR (0.35) | ALOX15CASP1ESR1HSD17B10 | |
| SCHEMBL4442926 | 0.68 | CDK2 (0.44) | ALDH1A1LMNAMAPTALOX15MEN1 | |
| SCHEMBL4450271 | 0.68 | HDAC1 (0.53) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3939770 | 0.67 | KDR (0.43) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1776218 | 0.65 | CA12 (0.45) | HAO2 | |
| SCHEMBL3979218 | 0.65 | — | — | |
| SCHEMBL15668778 | 0.62 | MYC (0.68) | MYCNR4A1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049106-A2 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008007113-A2 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |