Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2799890 | 0.88 | KMT2A (0.53) | HDAC1CCNA2CDK2MEN1KMT2A | |
| SCHEMBL3939511 | 0.87 | LMNA (0.48) | HDAC1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2801723 | 0.87 | KMT2A (0.54) | HDAC1HDAC2CCNA2CDK2MEN1 | |
| SCHEMBL3942467 | 0.86 | CDK2 (0.48) | HDAC1CCNA2CDK2MEN1KMT2A | |
| SCHEMBL3936265 | 0.84 | KMT2A (0.47) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL954639 | 0.82 | RAB9A (0.64) | CCNA2CDK2MEN1KMT2ANPC1 | |
| SCHEMBL4442926 | 0.81 | CDK2 (0.44) | HDAC1CCNA2CDK2MEN1KMT2A | |
| SCHEMBL2801400 | 0.81 | L3MBTL1 (0.53) | HDAC1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3937911 | 0.80 | KMT2A (0.43) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL3940057 | 0.79 | ALDH1A1 (0.46) | MEN1KMT2AMAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049106-A2 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008007113-A2 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |