Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27719984 | 0.87 | KDM1A (0.41) | KDM1AKDM4ELMNAMEN1ALDH1A1 | |
| SCHEMBL15364638 | 0.79 | TDP1 (0.39) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL15364640 | 0.79 | TDP1 (0.39) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL15364226 | 0.77 | TDP1 (0.40) | KDM1AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL15364227 | 0.77 | TDP1 (0.40) | KDM1AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL15364558 | 0.76 | KDM1A (0.41) | KDM1AKDM4ELMNAMEN1ALDH1A1 | |
| SCHEMBL15364556 | 0.76 | KDM1A (0.41) | KDM1AKDM4ELMNAMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4446458 | 0.76 | HPGD (0.38) | KDM1ALMNAMEN1ALDH1A1MAPT | |
| SCHEMBL15364480 | 0.74 | KDM1A (0.42) | KDM1ALMNAMEN1ALDH1A1MAPT | |
| SCHEMBL15364479 | 0.74 | KDM1A (0.42) | KDM1ALMNAMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595413-B2 | Phosphine-substituted vinyl containing metallocene catalyst, preparation process and the application of the same | PETROCHINA COMPANY LIMITED (CN) | 2009-09-29 | — | — | US | disclosed |
| EP-1958969-A1 | A phosphine-substituted vinyl containing metallocene catalyst, preparation process and the application of the same | Petrochina Company Limited (CN) | 2008-08-20 | — | — | EP | disclosed |
| US-20080194854-A1 | Phosphine-substituted vinyl containing metallocene catlyst, preparation process and the application of the same | PETROCHINA COMPANY LIMITED (CN) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194854-A1 | Phosphine-substituted vinyl containing metallocene catlyst, preparation process and the application of the same | PI4K2B, PI4K2A, CPNE4 | KDM1A 963/4885KDM4E 835/4885LMNA 3023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.