Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4452589 | 0.96 | AKR1C1 (0.41) | AKR1C1CYP19A1CYP11B2PRMT1ESR1 | |
| Hydrochloric Acid SCHEMBL4444570 | 0.96 | AKR1C1 (0.41) | AKR1C1CYP19A1CYP11B2PRMT1ESR1 | |
| SCHEMBL29236475 | 0.96 | AKR1C1 (0.44) | AKR1C1CYP19A1CYP11B2PRMT1ESR1 | |
| SCHEMBL27792105 | 0.92 | AKR1C1 (0.41) | AKR1C1CYP19A1CYP11B2PRMT1ESR1 | |
| SCHEMBL27813474 | 0.91 | AKR1C1 (0.40) | AKR1C1CYP19A1CYP11B2PRMT1ESR1 | |
| SCHEMBL27813473 | 0.89 | AKR1C1 (0.39) | AKR1C1CYP19A1CYP11B2PRMT1ESR1 | |
| Hydrochloric Acid SCHEMBL4449234 | 0.84 | MAPT (0.45) | MAPTALDH1A1LMNAPOLBMEN1 | |
| Hydrochloric Acid SCHEMBL4557365 | 0.80 | AKR1C1 (0.30) | AKR1C1MEN1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL4452464 | 0.78 | AKR1C1 (0.42) | AKR1C1CYP19A1CYP11B2PRMT1ESR1 | |
| Hydrochloric Acid SCHEMBL4454009 | 0.74 | AKR1C1 (0.39) | AKR1C1CYP19A1CYP11B2PRMT1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595413-B2 | Phosphine-substituted vinyl containing metallocene catalyst, preparation process and the application of the same | PETROCHINA COMPANY LIMITED (CN) | 2009-09-29 | — | — | US | disclosed |
| EP-1958969-A1 | A phosphine-substituted vinyl containing metallocene catalyst, preparation process and the application of the same | Petrochina Company Limited (CN) | 2008-08-20 | — | — | EP | disclosed |
| US-20080194854-A1 | Phosphine-substituted vinyl containing metallocene catlyst, preparation process and the application of the same | PETROCHINA COMPANY LIMITED (CN) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194854-A1 | Phosphine-substituted vinyl containing metallocene catlyst, preparation process and the application of the same | PI4K2B, PI4K2A, CPNE4 | ACHE 3120/4885AKR1C1 2150/4885CYP19A1 1230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.