SCHEMBL4452887

SCHEMBL4452887

Clc1ccc(-c2cccc(Cl)c2Cl)cc1Cl

nearest known ligand 0.69

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AHR P35869 6/20 0.69
CYP1B1 Q16678 1/20 0.52
CNR2 P34972 4/20 0.46
HSD11B1 P28845 1/20 0.45
EIF4E P06730 1/20 0.44
PTGER1 P34995 1/20 0.44
PTGER3 P43115 1/20 0.44
PTGER2 P43116 1/20 0.44
DHODH Q02127 1/20 0.43
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C19 P33261 1/20 0.41
RAB9A P51151 1/20 0.41
ATM Q13315 1/20 0.41
HSD17B10 Q99714 1/20 0.41
CNR1 P21554 1/20 0.41
DHFR P00374 1/20 0.41
RORB Q92753 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2282125 0.82 AHR (1.00) AHRCYP1B1KDM4ERAB9ADHFR
SCHEMBL3111742 0.82 AHR (0.60) AHRCYP1B1HSD11B1PTGER1PTGER3
SCHEMBL29617534 0.82 AHR (0.60) AHRCYP1B1HSD11B1PTGER1PTGER3
SCHEMBL4456546 0.82 AHR (0.64) AHRCYP1B1CNR2DHODHCNR1
SCHEMBL31339478 0.82 AHR (0.47) AHRCNR2DHODHCNR1
SCHEMBL2497910 0.79 AHR (0.52) AHRCYP1B1HSD11B1PTGER1PTGER3
SCHEMBL4445051 0.78 TDO2 (0.44) AHRCNR2DHFRRORB
SCHEMBL21076067 0.78 GSTP1 (0.52) AHRCNR2
SCHEMBL31339482 0.78 CNR2 (0.42) AHRCNR2DHODHCNR1
SCHEMBL4453342 0.77 CNR2 (0.53) AHRCNR2DHODHKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119193308-A Microorganism real-time tracking detection and drug sensitivity analysis system 海南微氪生物科技股份有限公司 2024-12-27 CN disclosed
US-20240226160-A9 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2024-07-11 US disclosed
US-20240131072-A1 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2024-04-25 US disclosed
EP-4291571-A2 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN Seattle Children's Hospital d/b/a Seattle Children's Research Institute (US) 2023-12-20 EP disclosed
US-20230330725-A1 VOLATILIZATION AND OXIDATION OF ORGANIC WASTE NATIONAL BANK OF CANADA (CA) 2023-10-19 US disclosed
US-20230322925-A1 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS SEATTLE CHILDREN’S HOSPITAL DBA SEATTLE CHILDREN’S RES INSTITUTE (US) 2023-10-12 US disclosed
CN-111758186-B Multilayer antenna 高通股份有限公司 2023-06-13 CN disclosed
US-20230172981-A1 METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST (US) 2023-06-08 US disclosed
CN-116234161-A Circuit board and computing device 超聚变数字技术有限公司 2023-06-06 CN disclosed
US-11649288-B2 Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents SEATTLE CHILDREN'S HOSPITAL (US) 2023-05-16 US disclosed
WO-2022174035-A2 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2022-08-18 WO disclosed
CN-114750637-A Distributed battery management system for electric vehicle 泰加汽车股份有限公司 2022-07-15 CN disclosed
CN-114632248-A Catheter for use in a respiratory device 瑞思迈私人有限公司 2022-06-17 CN disclosed
CN-110141752-B Catheter for use in a respiratory device 瑞思迈私人有限公司 2022-03-04 CN disclosed
US-20200087399-A1 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS Seattle Children's Hospital (dba Seattle Children's Research Institute) 2020-03-19 US disclosed
WO-2018148224-A1 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) 2018-08-16 WO disclosed
US-20170001052-A1 METHOD FOR ACTIVATING OXYGENASE-CONTAINING COMPOSITION AND CONTAMINANT DETOXIFICATION METHOD AND DEVICE BASED ON SAME TAKAHATA ELECTRONICS CORPORATION (JP) 2017-01-05 US disclosed
US-20090269857-A1 Instruments for detecting low-molecular weight substance FUJIKURA KASEI CO., LTD. (JP) 2009-10-29 US disclosed
US-20050148097-A1 Instruments for detecting low-molecular weight substance ENBIOTEC LABORATORIES C., LTD. (JP) 2005-07-07 US disclosed
EP-1489420-A1 INSTRUMENTS FOR DETECTING LOW-MOLECULAR WEIGHT SUBSTANCE Enbiotec Laboratories Co., Ltd. (JP) 2004-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11649288-B2 Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents PHOSPHO1, LCAT, CD47 AHR 765/4885CYP1B1 4745/4885CNR2 614/4885
US-20230322925-A1 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS PHOSPHO1, LCAT, CD47 AHR 765/4885CYP1B1 4745/4885CNR2 614/4885
US-20200087399-A1 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS PHOSPHO1, LCAT, CD47 AHR 765/4885CYP1B1 4745/4885CNR2 614/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.