Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.48 |
| ▸ | GUSB | P08236 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457091 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2HTTNTRK1RXFP1GUSB | |
| SCHEMBL4451021 | 0.87 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTRXFP1GUSBRAB9A | |
| SCHEMBL3038535 | 0.84 | HTT (0.56) | SMN1; SMN2HTTNTRK1GUSBRAB9A | |
| SCHEMBL4453257 | 0.81 | TP53 (0.59) | SMN1; SMN2HTTNTRK1RXFP1RAB9A | |
| SCHEMBL3044840 | 0.81 | MEN1 (0.67) | SMN1; SMN2HTTNTRK1RAB9ANPC1 | |
| SCHEMBL3037995 | 0.80 | RXFP1 (0.63) | SMN1; SMN2HTTRXFP1POLBMEN1 | |
| SCHEMBL3045782 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2HTTNTRK1GUSBPOLB | |
| SCHEMBL3035200 | 0.79 | SMN1; SMN2 (0.65) | SMN1; SMN2HTTRXFP1GUSBRAB9A | |
| SCHEMBL3031989 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2HTTRXFP1GUSBRAB9A | |
| SCHEMBL4453414 | 0.76 | MEN1 (0.66) | SMN1; SMN2RAB9ANPC1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | claimed |
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |