Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457091 | 0.89 | SMN1; SMN2 (0.53) | TP53RXFP1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3038535 | 0.87 | HTT (0.56) | RAB9ANPC1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL3045782 | 0.82 | SMN1; SMN2 (0.51) | TP53SMN1; SMN2HTTALDH1A1POLB | |
| SCHEMBL4453253 | 0.81 | SMN1; SMN2 (0.58) | TP53RXFP1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3035200 | 0.80 | SMN1; SMN2 (0.65) | TP53RXFP1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3044840 | 0.78 | MEN1 (0.67) | RAB9ANPC1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL3037995 | 0.76 | RXFP1 (0.63) | TP53RXFP1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL3042961 | 0.76 | LMNA (0.52) | TP53RXFP1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12584403 | 0.74 | RXFP1 (1.00) | TP53RXFP1SMN1; SMN2KDM4E | |
| SCHEMBL3043481 | 0.74 | LMNA (0.50) | TP53SMN1; SMN2HTTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | claimed |
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |