Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.65 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.62 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.62 |
| ▸ | JAK3 | P52333 | 5/20 | 0.60 |
| ▸ | JAK1 | P23458 | 3/20 | 0.59 |
| ▸ | TYK2 | P29597 | 2/20 | 0.59 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374484 | 0.84 | JAK2 (0.75) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4378148 | 0.84 | JAK2 (0.78) | JAK2JAK3JAK1TYK2CAMK2D | |
| SCHEMBL4388319 | 0.83 | JAK2 (0.58) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4393215 | 0.83 | JAK2 (0.58) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4378310 | 0.81 | JAK2 (0.86) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12801556 | 0.80 | JAK2 (0.71) | JAK2MYLK4STK17AJAK3JAK1 | |
| SCHEMBL12801543 | 0.80 | JAK2 (0.67) | JAK2JAK3CAMK2DSMG1 | |
| SCHEMBL13226352 | 0.80 | JAK2 (0.70) | JAK2STK17AJAK3JAK1TYK2 | |
| SCHEMBL4385348 | 0.80 | JAK2 (0.79) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL4386596 | 0.80 | JAK2 (0.79) | JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |