Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 6/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | PRCP | P42785 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14347878 | 0.85 | CHRM2 (0.47) | CHRM2CHRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7185401 | 0.85 | CHRM2 (0.78) | CHRM2CHRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8355804 | 0.81 | CHRM2 (0.43) | CHRM2CHRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2089640 | 0.78 | SLC6A4 (0.59) | CHRM2CHRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8353947 | 0.78 | KCNH2 (0.42) | CHRM2CHRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL14347820 | 0.77 | CHRM2 (0.39) | CHRM2CHRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL10607505 | 0.76 | DPP4 (0.53) | CHRM2CHRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9330358 | 0.75 | DPP4 (0.63) | CHRM2CHRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL15568275 | 0.75 | SLC6A4 (0.56) | CHRM2CHRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL28280766 | 0.74 | SLC6A4 (0.59) | CHRM2CHRM1SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130289021-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR PREVENTING, TREATING, OR REVERSING NEURONAL DYSFUNCTION | VOLVOVITZ FRANKLIN (US) | 2013-10-31 | — | — | US | disclosed |
| US-8299062-B2 | Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction | VOLVOVITZ FRANKLIN (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120264741-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR PREVENTING, TREATING, OR REVERSING NEURONAL DYSFUNCTION | VOLVOVITZ FRANKLIN (US) | 2012-10-18 | — | — | US | disclosed |
| US-20090048234-A1 | Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction | VOLVOVITZ FRANKLIN | 2009-02-19 | — | — | US | disclosed |
| US-20080090808-A1 | Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction | VOLVOVITZ FRANKLIN | 2008-04-17 | — | — | US | disclosed |