Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 16/20 | 0.71 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4455871 | 0.88 | F10 (0.65) | F10PTGS2 | |
| SCHEMBL4447306 | 0.87 | F10 (0.55) | F10MAPT | |
| SCHEMBL4448086 | 0.87 | F10 (0.64) | F10PTGS2 | |
| SCHEMBL4446662 | 0.85 | F10 (0.54) | F10 | |
| SCHEMBL4454250 | 0.85 | F10 (0.54) | F10 | |
| SCHEMBL76892 | 0.83 | F10 (1.00) | F10PTGS2MAPT | |
| SCHEMBL76023 | 0.83 | F10 (1.00) | F10PTGS2MAPT | |
| SCHEMBL76143 | 0.83 | F10 (1.00) | F10PTGS2MAPT | |
| SCHEMBL76849 | 0.83 | F10 (1.00) | F10PTGS2MAPT | |
| SCHEMBL77859 | 0.83 | F10 (1.00) | F10PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557102-B2 | Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses | MERCK PATENT GMBH (DE) | 2009-07-07 | — | — | US | claimed |
| EP-1608645-B1 | PYRAZOLIDINE-1,2-DICARBOXYLDIPHENYLAMIDE DERIVATIVES AS COAGULATION FACTOR XA INHIBITORS FOR THE TREATMENT OF THROMBOSES | MERCK PATENT GMBH (DE) | 2007-05-02 | — | — | EP | claimed |
| US-20060183742-A1 | Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses | MERCK PATENT GMBH (DE) | 2006-08-17 | — | — | US | claimed |
| US-7557102-B2 | Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses | MERCK PATENT GMBH (DE) | 2009-07-07 | — | — | US | disclosed |
| US-20060183742-A1 | Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses | MERCK PATENT GMBH (DE) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183742-A1 | Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses | F2, SERPINC1, F12 | F10 7/4885PTGS2 1348/4885MAPT 4742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.