SCHEMBL4454350

SCHEMBL4454350

Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CCN(CC(=O)CCC(C)C)CC1.Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CCN(CC(=O)CCCC(C)C)CC1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.65
CYP2C9 P11712 2/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL389205 0.98 GPR119 (0.66) GPR119CYP2C9
SCHEMBL390447 0.97 GPR119 (0.68) GPR119CYP2C9
SCHEMBL4454353 0.91 GPR119 (0.57) GPR119CYP2C9
SCHEMBL386100 0.90 GPR119 (0.64) GPR119CYP2C9
SCHEMBL1889155 0.89 GPR119 (0.64) GPR119CYP2C9
SCHEMBL389473 0.89 GPR119 (0.70) GPR119CYP2C9
SCHEMBL390879 0.88 GPR119 (0.74) GPR119CYP2C9
SCHEMBL388981 0.88 GPR119 (0.66) GPR119CYP2C9
SCHEMBL390782 0.88 GPR119 (0.65) GPR119CYP2C9
SCHEMBL390765 0.88 GPR119 (0.67) GPR119CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2116235-A1 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level Arena Pharmaceuticals, Inc. (US) 2009-11-11 EP disclosed