SCHEMBL445471

SCHEMBL445471

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nearest known ligand 0.62

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.62
SLC1A1 P43005 5/20 0.56
SLC1A3 P43003 5/20 0.54
SLC1A2 P43004 5/20 0.54
PTGS1 P23219 1/20 0.52
SLC7A11 Q9UPY5 1/20 0.52
ENPEP Q07075 1/20 0.52
GRIK1 P39086 4/20 0.50
GRIK2 Q13002 4/20 0.50
GGT1 P19440 2/20 0.50
GRM1 Q13255 1/20 0.50
GRM2 Q14416 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL39093 1.00 SLC7A5 (0.62) SLC7A5SLC1A1SLC1A3SLC1A2PTGS1
SCHEMBL148584 1.00 SLC7A5 (0.62) SLC7A5SLC1A1SLC1A3SLC1A2PTGS1
SCHEMBL4303994 1.00 SLC7A5 (0.62) SLC7A5SLC1A1SLC1A3SLC1A2PTGS1
Glycine SCHEMBL10994359 0.89 SLC7A5 (0.52) SLC7A5SLC1A1SLC1A3SLC1A2PTGS1
Aspartic Acid SCHEMBL22557639 0.89 SLC7A5 (0.52) SLC7A5SLC1A1SLC1A3SLC1A2PTGS1
Serine SCHEMBL6827952 0.89 SLC1A1 (0.60) SLC7A5SLC1A1SLC1A3SLC1A2PTGS1
Alanine SCHEMBL10991017 0.89 SLC7A5 (0.65) SLC7A5SLC1A1SLC1A3SLC1A2PTGS1
SCHEMBL600881 0.87 SLC7A5 (0.68) SLC7A5SLC1A1SLC1A3SLC1A2PTGS1
SCHEMBL9545322 0.87 SLC7A5 (0.68) SLC7A5SLC1A1SLC1A3SLC1A2PTGS1
SCHEMBL29024969 0.87 SLC7A5 (0.68) SLC7A5SLC1A1SLC1A3SLC1A2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120064075-A1 CHIMERIC FACTOR VII MOLECULES WITH ENHANCED HALF LIFE AND METHODS OF USE INSPIRATION BIOPHARMACEUTICALS, INC. 2012-03-15 US disclosed
EP-1432794-B1 HUMAN COAGULATION FACTOR VII POLYPEPTIDES NOVO NORDISK HEALTHCARE AG (CH) 2011-11-09 EP disclosed
WO-2011092242-A1 FACTOR VII FUSION POLYPEPTIDES NOVO NORDISK HEALTH CARE AG (CH) 2011-08-04 WO disclosed
EP-2316930-A1 Human coagulation factor VII polypeptides Novo Nordisk Health Care AG (CH) 2011-05-04 EP disclosed
US-20110040073-A1 Covalent Factor VII-Tissue Factor Complex NOVO NORDISK HEALTHCARE A/G (CH) 2011-02-17 US disclosed
US-6235707-B1 Anticoagulant peptidyl-arginine aldehyde derivatives GYOGYSZERKUTATO INTEZET KFT. (HU) 2001-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110040073-A1 Covalent Factor VII-Tissue Factor Complex F13B, F7, HABP2 SLC7A5 3724/4885SLC1A1 4667/4885SLC1A3 4695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.