Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454629 | 0.93 | IGF1R (0.77) | IGF1RMAPTALDH1A1SIRT5NPC1 | |
| SCHEMBL14050600 | 0.92 | IGF1R (0.56) | IGF1RMAPTKMT2AHPGDMEN1 | |
| SCHEMBL14050422 | 0.82 | IGF1R (0.65) | IGF1RMAPTALDH1A1SIRT5SMN1; SMN2 | |
| SCHEMBL15109596 | 0.81 | IGF1R (0.60) | IGF1RMAPTALDH1A1SIRT5NPC1 | |
| SCHEMBL4454742 | 0.80 | IGF1R (0.62) | IGF1RSIRT5 | |
| SCHEMBL4454739 | 0.79 | IGF1R (0.76) | IGF1R | |
| SCHEMBL13236125 | 0.78 | IGF1R (0.54) | IGF1RMAPTKMT2AHPGDMEN1 | |
| SCHEMBL12438424 | 0.77 | IGF1R (0.59) | IGF1RMAPTKMT2AHPGDMEN1 | |
| SCHEMBL11344922 | 0.77 | IGF1R (0.76) | IGF1RMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL11342777 | 0.77 | IGF1R (0.77) | IGF1RMAPTKMT2AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |