Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 8/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14297340 | 0.72 | KDM4E (0.76) | POLBKDM4ELMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL15033485 | 0.71 | POLB (1.00) | POLBKDM4ELMNAHSD17B10USP2 | |
| SCHEMBL26789169 | 0.70 | USP2 (0.70) | POLBKDM4ELMNAUSP2SMN1; SMN2 | |
| SCHEMBL26789172 | 0.70 | USP2 (0.70) | POLBKDM4ELMNAUSP2SMN1; SMN2 | |
| SCHEMBL25739943 | 0.70 | SMN1; SMN2 (0.70) | POLBKDM4ELMNAHSD17B10USP2 | |
| SCHEMBL4055789 | 0.70 | SMN1; SMN2 (0.70) | POLBKDM4ELMNAHSD17B10USP2 | |
| SCHEMBL8288440 | 0.70 | SMN1; SMN2 (0.70) | POLBKDM4ELMNAHSD17B10USP2 | |
| SCHEMBL8288443 | 0.70 | SMN1; SMN2 (0.70) | POLBKDM4ELMNAHSD17B10USP2 | |
| SCHEMBL4051295 | 0.70 | SMN1; SMN2 (0.70) | POLBKDM4ELMNAHSD17B10USP2 | |
| SCHEMBL3154658 | 0.70 | USP2 (0.70) | POLBKDM4ELMNAUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |