Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTPRF | P10586 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPRA | P18433 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29262764 | 0.77 | CYP2D6 (0.52) | TLR8CYP2D6ALDH1A1MAPTKMT2A | |
| SCHEMBL3786585 | 0.74 | PKM (0.43) | DHFR | |
| SCHEMBL468531 | 0.74 | CYP2D6 (0.53) | TLR8CYP2D6ALDH1A1MAPTKMT2A | |
| SCHEMBL20434300 | 0.71 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL1090895 | 0.70 | TLR8 (0.46) | TLR8CYP2D6ALDH1A1MAPTKMT2A | |
| SCHEMBL3778205 | 0.69 | PKM (0.43) | HRH4HRH3DHFR | |
| SCHEMBL10495187 | 0.69 | PTPRF (0.42) | TLR8MAPTKMT2APTPRFPTPN1 | |
| SCHEMBL3784037 | 0.68 | HRH4 (0.43) | HRH4HRH3DHFR | |
| SCHEMBL20242690 | 0.68 | TLR8 (0.59) | TLR8TLR7SLC2A1DHFR | |
| SCHEMBL30035562 | 0.68 | TLR8 (0.59) | TLR8TLR7SLC2A1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |