SCHEMBL445516

SCHEMBL445516

c1cc2cc3ccncc3cc2cn1

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CLK1 P49759 2/20 0.57
CSNK1D P48730 1/20 0.57
CSNK1E P49674 1/20 0.57
DYRK1A Q13627 1/20 0.57
PRKCZ Q05513 1/20 0.50
HASPIN Q8TF76 10/20 0.48
PIM1 P11309 3/20 0.48
CCNT1 O60563 3/20 0.48
CDK9 P50750 3/20 0.48
CYP19A1 P11511 2/20 0.45
MAPT P10636 1/20 0.44
MELK Q14680 1/20 0.44
IKBKB O14920 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4036768 1.00 CLK1 (0.57) CLK1CSNK1DCSNK1EDYRK1APRKCZ
SCHEMBL13156497 0.97 CLK1 (0.55) CLK1CSNK1DCSNK1EDYRK1APRKCZ
SCHEMBL13156539 0.97 CLK1 (0.55) CLK1CSNK1DCSNK1EDYRK1APRKCZ
SCHEMBL13156496 0.97 CLK1 (0.55) CLK1CSNK1DCSNK1EDYRK1APRKCZ
SCHEMBL13156508 0.97 CLK1 (0.55) CLK1CSNK1DCSNK1EDYRK1APRKCZ
SCHEMBL445029 0.92 CLK1 (0.52) CLK1CSNK1DCSNK1EDYRK1APRKCZ
SCHEMBL13156540 0.89 CLK1 (0.50) CLK1CSNK1DCSNK1EDYRK1APRKCZ
SCHEMBL1512981 0.89 CLK1 (0.50) CLK1CSNK1DCSNK1EDYRK1APRKCZ
Methane SCHEMBL29190811 0.89 CLK1 (0.50) CLK1CSNK1DCSNK1EDYRK1APRKCZ
Charcoal, Activated SCHEMBL30641848 0.89 CLK1 (0.50) CLK1CSNK1DCSNK1EDYRK1APRKCZ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9207234-B2 Thermally stable SERS taggants SICPA HOLDING SA (CH) 2015-12-08 US claimed
EP-2433121-A1 THERMALLY STABLE SERS TAGGANTS Cabot Security Materials Inc. (US) 2012-03-28 EP claimed
US-20120062886-A1 Thermally Stable SERS Taggants CABOT SECURITY MATERIALS INC. (US) 2012-03-15 US claimed
WO-2010135351-A1 THERMALLY STABLE SERS TAGGANTS OXONICA MATERIALS INC. (US) 2010-11-25 WO claimed
US-20020160972-A1 Compositions and methods for modulating RNA ISIS PHARMACEUTICALS, INC. 2002-10-31 US claimed
US-6358931-B1 OLIGONUCLETIDE CONJUGATED TO IMIDAZOLE; INTERCALATION AND COORDINATION COMPOUNDS; MEDICAL DIAGNOSIS, GENE THERAPY; ANTISENSE AGENTS ISIS PHARMACEUTICALS, INC. 2002-03-19 US claimed
US-5994365-A BACTERICIDES; FUNGICIDES; ANTITUMOR AGENT DIAZANS LIMITED (CA) 1999-11-30 US claimed
EP-0656790-A1 COMPOSITIONS AND METHODS FOR MODULATING RNA ISIS PHARMACEUTICALS, INC. (US) 1995-06-14 EP claimed
WO-1993017717-A1 COMPOSITIONS AND METHODS FOR MODULATING RNA ISIS PHARMACEUTICALS, INC. (US) 1993-09-16 WO claimed
US-20250073225-A1 BIFUNCTIONAL COMPOSITIONS FOR THE TREATMENT OF CANCER ARMACEUTICA INC (US) 2025-03-06 US disclosed
US-12201626-B2 Bifunctional compositions for the treatment of cancer Armaceutica, Inc. (US) 2025-01-21 US disclosed
EP-3793544-B1 BIFUNCTIONAL COMPOSITIONS FOR THE TREATMENT OF CANCER ARMACEUTICA INC (US) 2023-09-20 EP disclosed
US-20220288100-A1 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS IONIS PHARMACEUTICALS, INC. (US) 2022-09-15 US disclosed
US-20210361643-A1 BIFUNCTIONAL COMPOSITIONS FOR THE TREATMENT OF CANCER ARMACEUTICA INC (US) 2021-11-25 US disclosed
US-6060592-A Pyrimidine nucleoside compounds and oligonucleoside compounds containing same ISIS PHARMACEUTICALS, INC. (US) 2000-05-09 US disclosed
US-5994365-A BACTERICIDES; FUNGICIDES; ANTITUMOR AGENT DIAZANS LIMITED (CA) 1999-11-30 US disclosed
US-5514786-A Compositions for inhibiting RNA activity ISIS PHARMACEUTICALS, INC. (US) 1996-05-07 US disclosed
WO-1995024185-A1 NOVEL PYRIMIDINE NUCLEOSIDES ISIS PHARMACEUTICALS, INC. (US) 1995-09-14 WO disclosed
EP-0656790-A1 COMPOSITIONS AND METHODS FOR MODULATING RNA ISIS PHARMACEUTICALS, INC. (US) 1995-06-14 EP disclosed
WO-1993017717-A1 COMPOSITIONS AND METHODS FOR MODULATING RNA ISIS PHARMACEUTICALS, INC. (US) 1993-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020160972-A1 Compositions and methods for modulating RNA RNGTT, NSUN3, NSUN2 CLK1 4180/4885CSNK1D 2593/4885CSNK1E 1856/4885
US-20220288100-A1 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS NSUN2, SNRPE, RBM3 CLK1 3485/4885CSNK1D 3997/4885CSNK1E 2989/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.