Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | PBK | Q96KB5 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1968452 | 0.90 | HSD11B1 (0.47) | HSD11B1IDH1 | |
| SCHEMBL1970498 | 0.87 | HSD11B1 (0.41) | HSD11B1ALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL1973706 | 0.86 | HSD11B1 (0.46) | HSD11B1 | |
| SCHEMBL1972364 | 0.85 | CNR2 (0.41) | HSD11B1ALDH1A1KDM4ERAB9AHPGD | |
| SCHEMBL1970094 | 0.84 | MEN1 (0.48) | HSD11B1KMT2AMEN1IDH1 | |
| SCHEMBL1968067 | 0.84 | HSD11B1 (0.51) | HSD11B1ALDH1A1RAB9AIDH1 | |
| SCHEMBL1970096 | 0.83 | HSD11B1 (0.51) | HSD11B1 | |
| SCHEMBL1969400 | 0.82 | HSD11B1 (0.51) | HSD11B1IDH1 | |
| SCHEMBL1967072 | 0.82 | HSD11B1 (0.52) | HSD11B1IDH1 | |
| SCHEMBL1967351 | 0.82 | HSD11B1 (0.61) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086939-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-08-12 | — | — | EP | claimed |
| WO-2008053194-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | claimed |