Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | OGA | O60502 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28373607 | 0.82 | HDAC3 (0.56) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL23988327 | 0.82 | OGA (0.44) | HRH3PTPN11OGAHDAC3HDAC1 | |
| SCHEMBL23251484 | 0.82 | OGA (0.44) | HRH3PTPN11OGAHDAC3HDAC1 | |
| SCHEMBL4467331 | 0.81 | HRH3 (0.69) | HRH3OGA | |
| SCHEMBL20917117 | 0.80 | POLB (0.50) | PTPN11HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL24126684 | 0.79 | HRH3 (0.44) | HRH3OGAHDAC3HDAC1HDAC2 | |
| SCHEMBL4790004 | 0.78 | POLB (0.49) | PTPN11HDAC6POLB | |
| SCHEMBL1126338 | 0.78 | OGA (0.53) | HRH3PTPN11OGA | |
| SCHEMBL4456976 | 0.78 | PTPN11 (0.48) | HRH3PTPN11HDAC3HDAC1HDAC2 | |
| SCHEMBL63785 | 0.77 | OGA (0.57) | HRH3PTPN11OGAHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | disclosed |