Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033046 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1PKMPOLBALDH1A1 | |
| SCHEMBL3039687 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1PKMALDH1A1HTT | |
| SCHEMBL3043122 | 0.86 | HPGD (0.50) | SMN1; SMN2L3MBTL1PKMHTTMAPT | |
| SCHEMBL3035759 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1PKMALDH1A1HTT | |
| SCHEMBL4455947 | 0.83 | HTT (0.38) | SMN1; SMN2POLBALDH1A1HTTMAPT | |
| SCHEMBL3048622 | 0.82 | POLB (0.62) | SMN1; SMN2L3MBTL1PKMPOLBALDH1A1 | |
| SCHEMBL3039180 | 0.81 | POLB (0.52) | SMN1; SMN2L3MBTL1PKMPOLBALDH1A1 | |
| SCHEMBL3037886 | 0.81 | RXFP1 (0.57) | SMN1; SMN2L3MBTL1PKMPOLBALDH1A1 | |
| SCHEMBL3042107 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2L3MBTL1PKMPOLBALDH1A1 | |
| SCHEMBL3042892 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1PKMPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2042490-A2 | Benzimidazole derivatives as vanilloid receptor antagonists | AstraZeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |
| CN-1784387-A | Novel benzimidazole derivatives | ASTRAZENECA AB (SE) | 2006-06-07 | — | — | CN | disclosed |