Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4455944 | 0.83 | SMN1; SMN2 (0.47) | HTTMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3033046 | 0.83 | SMN1; SMN2 (0.47) | HTTMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4462954 | 0.76 | FGFR1 (0.42) | MEN1MAPTKMT2ANPSR1FGFR1 | |
| SCHEMBL3043306 | 0.72 | MAPK1 (0.46) | HTTMEN1MAPTKMT2AFGFR1 | |
| SCHEMBL3036275 | 0.68 | KMT2A (0.45) | HTTMEN1MAPTKMT2AFGFR1 | |
| SCHEMBL3039687 | 0.68 | SMN1; SMN2 (0.52) | HTTMEN1MAPTKMT2ATP53 | |
| SCHEMBL3043122 | 0.67 | HPGD (0.50) | HTTMEN1MAPTKMT2ATP53 | |
| SCHEMBL3035759 | 0.67 | SMN1; SMN2 (0.44) | HTTMEN1MAPTKMT2ATP53 | |
| SCHEMBL5804037 | 0.65 | CYP1A2 (0.59) | MAPTEPHX2HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL6160971 | 0.65 | EPHX2 (0.55) | HTTMEN1MAPTKMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2042490-A2 | Benzimidazole derivatives as vanilloid receptor antagonists | AstraZeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |