Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | STK3 | Q13188 | 1/20 | 0.40 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | MTOR | P42345 | 6/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464429 | 0.84 | PIK3CA (0.52) | KDM4EMEN1KMT2AUSP2HIF1A | |
| SCHEMBL7189256 | 0.82 | RAF1 (0.54) | KDM4ECLK2GSK3AGSK3BCSNK2A1 | |
| SCHEMBL7067699 | 0.80 | CNR1 (0.47) | KDM4EMEN1KMT2AUSP2HIF1A | |
| SCHEMBL6257285 | 0.80 | MTOR (0.41) | KDM4EMEN1KMT2AUSP2HIF1A | |
| SCHEMBL7069390 | 0.80 | EPHX2 (0.49) | KDM4ECLK2GSK3AGSK3BCSNK2A1 | |
| SCHEMBL5462710 | 0.79 | PIK3CA (0.40) | KDM4EMEN1KMT2AUSP2HIF1A | |
| SCHEMBL7064948 | 0.77 | KDM4E (0.45) | KDM4EMEN1KMT2AUSP2HIF1A | |
| SCHEMBL4086943 | 0.76 | MAPK14 (0.59) | MAPK1HIF1APIK3CAMTORPIK3CG | |
| SCHEMBL7070212 | 0.76 | MAPK14 (0.49) | MAPK1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL28747223 | 0.75 | CLK2 (0.49) | KDM4EMEN1KMT2AUSP2CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116245-A2 | EGFR kinase inhibitor combinations for treating respiratory and gastrointestinal disorders | Boehringer Ingelheim International GmbH (DE) | 2009-11-11 | — | — | EP | disclosed |