Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM4B | O94953 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.42 |
| ▸ | PNP | P00491 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 2/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Purine SCHEMBL29456595 | 0.82 | — | — | |
| Purine SCHEMBL2120547 | 0.82 | KDM4A (0.38) | ALDH1A1KDM4AKDM4BKDM5CKDM4C | |
| Purine SCHEMBL6421376 | 0.82 | KDM4A (0.38) | ALDH1A1KDM4AKDM4BKDM5CKDM4C | |
| Purine SCHEMBL3157 | 0.82 | — | — | |
| Purine SCHEMBL1389668 | 0.80 | KDM4A (0.37) | ALDH1A1KDM4AKDM4BKDM5CKDM4C | |
| Purine SCHEMBL7787135 | 0.80 | KDM4A (0.37) | ALDH1A1KDM4AKDM4BKDM5CKDM4C | |
| Purine SCHEMBL5578775 | 0.80 | KDM4A (0.37) | ALDH1A1KDM4AKDM4BKDM5CKDM4C | |
| Purine SCHEMBL37119 | 0.80 | KDM4A (0.37) | ALDH1A1KDM4AKDM4BKDM5CKDM4C | |
| Purine SCHEMBL9057416 | 0.80 | KDM4A (0.37) | ALDH1A1KDM4AKDM4BKDM5CKDM4C | |
| Purine SCHEMBL6438162 | 0.80 | KDM4A (0.37) | ALDH1A1KDM4AKDM4BKDM5CKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090226439-A1 | METHOD FOR TREATING DEMENTIA OR ALZHEIMER'S DISEASE | GENENTECH, INC. (US) | 2009-09-10 | — | — | US | claimed |
| CN-101203242-A | Methods of treating dementia or Alzheimer's disease with CD20 antibodies | GENENTECH INC (US) | 2008-06-18 | — | — | CN | claimed |
| EP-1874350-A2 | METHOD FOR TREATING DEMENTIA OR ALZHEIMER'S DISEASE WITH A CD20 ANTIBODY | Genentech, Inc. (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006116369-A2 | METHOD FOR TREATING DEMENTIA OR ALZHEIMER'S DISEASE WITH A CD20 ANTIBODY | GENENTECH, INC. (US) | 2006-11-02 | — | — | WO | claimed |
| US-20060240007-A1 | Method for treating dementia or Alzheimer's disease | GENENTECH, INC. | 2006-10-26 | — | — | US | claimed |
| EP-4351661-A1 | RECOMBINANT ADENO-ASSOCIATED VIRUSES FOR LESCH-NYHAN DISORDERS AND USES THEREOF | The Trustees of The University of Pennsylvania (US) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022261187-A1 | RECOMBINANT ADENO-ASSOCIATED VIRUSES FOR LESCH-NYHAN DISORDERS AND USES THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2022-12-15 | — | — | WO | disclosed |
| US-20220133818-A1 | METHOD AND COMPOSITION FOR TREATING GASTROINTESTINAL INFLAMMATORY DISORDERS | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE | 2022-05-05 | — | — | US | disclosed |
| EP-3930735-A1 | METHOD AND COMPOSITION FOR TREATING GASTROINTESTINAL INFLAMMATORY DISORDERS | The Regents of the University of Colorado, a body corporate (US) | 2022-01-05 | — | — | EP | disclosed |
| CN-109072237-A | Compositions and methods for reducing expression of TAU | 诺华股份有限公司 | 2018-12-21 | — | — | CN | disclosed |
| EP-3259588-A1 | HIGH SENSITIVITY METHOD FOR EARLY LYME DISEASE DETECTION | Colorado State University Research Foundation (US) | 2017-12-27 | — | — | EP | disclosed |
| EP-3215633-A1 | SYSTEM, METHOD AND APPARATUS FOR DETERMINING THE EFFECT OF GENETIC VARIANTS | Metabolon, Inc. (US) | 2017-09-13 | — | — | EP | disclosed |
| US-5750729-A | REACTING PROTECTED PYRAN DERIVATIVES TO FORM NUCLEOTIDES | GILEAD SCIENCES,INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5693771-A | REACTING PROTECTED PYRAN COMPOUND WITH PHOSPHITE AND HETEROCYCLIC BASE | GILEAD SCIENCES, INC. (US) | 1997-12-02 | — | — | US | disclosed |
| EP-0807118-A2 | NOVEL COMPOUNDS AND METHODS FOR MAKING AND USING SAME | GILEAD SCIENCES, INC. (US) | 1997-11-19 | — | — | EP | disclosed |
| US-5659023-A | HETEROCYCLIC FURANOSYL OR PYRANOSYL PHOSPHONATE; IMMUNOGENS, OLIGONUCLEOTIDES, ANTIINFECTIVES, ANTIINFLAMMATORY AGENTS | GILEAD SCIENCES, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0772440-A1 | CARBON MONOXIDE DEPENDENT GUANYLYL CYCLASE MODIFIERS | GLASKY, Alvin J. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996023801-A2 | NOVEL COMPOUNDS AND METHODS FOR MAKING AND USING SAME | GILEAD SCIENCES, INC. (US) | 1996-08-08 | — | — | WO | disclosed |
| WO-1996003125-A1 | CARBON MONOXIDE DEPENDENT GUANYLYL CYCLASE MODIFIERS | GLASKY ALVIN J (US) | 1996-02-08 | — | — | WO | disclosed |
| US-5447939-A | Purine derivatives used for long term modification of neural activity in mammals, for treatment of mammalian neurological diseases, and for inducing long term changes in membrane potential of mammalian neuron | SPECTRUM PHARMACEUTICALS, INC. | 1995-09-05 | — | — | US | disclosed |