Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | RARA | P10276 | 2/20 | 0.33 |
| ▸ | RARB | P10826 | 2/20 | 0.33 |
| ▸ | RARG | P13631 | 2/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421841 | 0.81 | AKR1B1 (0.42) | AKR1B1AKR1B10MAPTAKR1A1APP | |
| SCHEMBL13160455 | 0.81 | AKR1B1 (0.41) | AKR1B1AKR1B10MAPTAKR1A1NR3C1 | |
| SCHEMBL3428327 | 0.77 | AKR1B1 (0.46) | AKR1B1AKR1B10MAPTAKR1A1APP | |
| SCHEMBL3426749 | 0.77 | AKR1B1 (0.55) | AKR1B1AKR1B10MAPTAKR1A1RIPK1 | |
| SCHEMBL3424437 | 0.74 | AKR1B1 (0.47) | AKR1B1AKR1B10MAPTAKR1A1RARA | |
| SCHEMBL12188672 | 0.74 | AKR1B1 (0.57) | AKR1B1AKR1B10MAPTAKR1A1RARA | |
| SCHEMBL3424115 | 0.74 | NR3C1 (0.61) | NR3C1PGRNR3C2 | |
| SCHEMBL3428145 | 0.73 | NR3C1 (0.61) | AKR1B1NR3C1PGRNR3C2KIF11 | |
| SCHEMBL3426706 | 0.73 | AKR1B1 (0.48) | AKR1B1AKR1B10MAPTAKR1A1RARA | |
| SCHEMBL3424941 | 0.73 | AKR1B1 (0.51) | AKR1B1AKR1B10MAPTAKR1A1RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051736-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST AND AN IMMUNOSUPPRESSIVE AGENT FOR TREATING DRY EYE | Bausch & Lomb Incorporated (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008005686-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST AND AN IMMUNOSUPPRESSIVE AGENT FOR TREATING DRY EYE | BAUSCH & LOMB INCORPORATED (US) | 2008-01-10 | — | — | WO | disclosed |