Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL192333 | 0.81 | PDCD1 (0.53) | PTGS2HPGDHSD17B10PDCD1CD274 | |
| SCHEMBL13176495 | 0.79 | NPC1 (0.47) | SLC6A4SLC6A3PTGS2SUCNR1CYP1A2 | |
| SCHEMBL2688189 | 0.79 | CYP1A2 (0.50) | SLC6A4SLC6A3PTGS2CYP1A2PTGS1 | |
| SCHEMBL28664909 | 0.73 | CD274 (0.50) | SLC6A4SLC6A3PTGS2SUCNR1CYP1A2 | |
| SCHEMBL12295922 | 0.71 | CYP1A2 (0.50) | SLC6A4SLC6A3PTGS2CYP1A2PTGS1 | |
| SCHEMBL9862848 | 0.70 | CYP1A2 (0.63) | SLC6A4SLC6A3PTGS2CYP1A2PTGS1 | |
| SCHEMBL172733 | 0.70 | NPC1 (0.59) | SLC6A4SLC6A3PTGS2CYP1A2PTGS1 | |
| SCHEMBL30493964 | 0.70 | NPC1 (0.59) | SLC6A4SLC6A3PTGS2CYP1A2PTGS1 | |
| SCHEMBL2815641 | 0.69 | — | — | |
| SCHEMBL4328698 | 0.69 | NPC1 (0.46) | SLC6A4SLC6A3PTGS2CYP1A2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2052251-A1 | COMBINATION 5-HT7 RECEPTOR ANTAGONIST AND SEROTONIN REUPTAKE INHIBITOR THERAPY | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008013556-A1 | COMBINATION 5-HT7 RECEPTOR ANTAGONIST AND SEROTONIN REUPTAKE INHIBITOR THERAPY | JANSSEN PHARMACEUTICAL N.V. (BE) | 2008-01-31 | — | — | WO | disclosed |