Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12749679 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2HCRTR1HCRTR2MAPTKDM4E | |
| SCHEMBL1470406 | 0.83 | HDAC8 (0.50) | SMN1; SMN2HCRTR1HCRTR2MAPTKDM4E | |
| SCHEMBL12749820 | 0.83 | HDAC8 (0.50) | SMN1; SMN2HCRTR1HCRTR2MAPTKDM4E | |
| SCHEMBL16803490 | 0.77 | KDM4E (0.52) | SMN1; SMN2MAPTKDM4ECNR2CNR1 | |
| SCHEMBL16648616 | 0.77 | KDM4E (0.71) | SMN1; SMN2MAPTKDM4EABL1LMNA | |
| SCHEMBL1470612 | 0.76 | KDM4E (0.51) | SMN1; SMN2HCRTR1HCRTR2MAPTKDM4E | |
| SCHEMBL1470609 | 0.76 | KDM4E (0.51) | SMN1; SMN2HCRTR1HCRTR2MAPTKDM4E | |
| SCHEMBL16803495 | 0.76 | KMT2A (0.57) | SMN1; SMN2HCRTR1HCRTR2MAPTKDM4E | |
| SCHEMBL6356656 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2HCRTR1HCRTR2MAPTKDM4E | |
| SCHEMBL9105531 | 0.75 | LMNA (0.46) | SMN1; SMN2HCRTR1HCRTR2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151744-A1 | S-NITROSOMERCAPTO COMPOUNDS AND RELATED DERIVATIVES | GALLEON PHARMACEUTICALS, INC. (US) | 2009-12-17 | — | — | WO | disclosed |