Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.42 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | BCHE | P06276 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1811008 | 0.87 | PTPN11 (0.42) | PTPN11PTPROACAT1 | |
| SCHEMBL1815761 | 0.87 | PTPN11 (0.56) | PTPN11PTPROACAT1CA12CA1 | |
| SCHEMBL2853646 | 0.85 | PTPN11 (0.39) | PTPN11PTPROACAT1CA12CA1 | |
| SCHEMBL1814176 | 0.84 | PTPN11 (0.43) | PTPN11PTPROACAT1 | |
| SCHEMBL1814184 | 0.83 | PTPN11 (0.52) | PTPN11PTPROACAT1CA12CA1 | |
| SCHEMBL13708340 | 0.82 | LTB4R2 (0.38) | PTPN11PTPROACAT1CA12CA1 | |
| SCHEMBL1811444 | 0.81 | PTPN11 (0.52) | PTPN11PTPROBCHECA12CA1 | |
| SCHEMBL1811360 | 0.81 | PTPN11 (0.56) | PTPN11PTPROACAT1CA12CA1 | |
| SCHEMBL2855304 | 0.81 | POLB (0.38) | PTPN11PTPROTDP1L3MBTL1 | |
| SCHEMBL1814897 | 0.80 | CNR2 (0.40) | ACAT1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589232-B2 | Alkynyl aryl carboxamides | LABORATORIES SERONO S.A. (CH) | 2009-09-15 | — | — | US | disclosed |
| US-20070105913-A1 | Alkynyl aryl carboxamides | APPLIED RESEARCH SYSTEMS ARS HOLDINGS N.V. (NL) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105913-A1 | Alkynyl aryl carboxamides | ECHS1, IRS1, HCCS | PTPN11 97/4885PTPRO 51/4885ACAT1 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.