ECHS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1554482	1.00	1/20
SCHEMBL1546914	0.89	1/20
SCHEMBL1547091	0.88	1/20
SCHEMBL1555902	0.88	1/20
SCHEMBL1547102	0.86	1/20
SCHEMBL1591314	0.85	1/20
SCHEMBL1546563	0.85	1/20
SCHEMBL1554516	0.84	1/20
SCHEMBL19061011	0.83	1/20
SCHEMBL1546814	0.83	1/20
SCHEMBL1546888	0.82	1/20
SCHEMBL12709130	0.81	1/20
SCHEMBL1546619	0.80	1/20
SCHEMBL1546626	0.80	1/20
SCHEMBL1546623	0.80	1/20
SCHEMBL1547123	0.80	1/20
SCHEMBL1546581	0.80	1/20
SCHEMBL1555938	0.80	1/20
SCHEMBL1546573	0.79	1/20
SCHEMBL1546663	0.79	1/20

Clinical trials — most relevant to ECHS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease	PHASE2	COMPLETED
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension	PHASE2	NOT_YET_RECRUITING
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC	PHASE1/PHASE2	UNKNOWN
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	PHASE2	RECRUITING
EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment	PHASE2	COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Epicardial Fat Tissue and Severity of Coronary Artery Disease in Diabetic vs Non Diabetic Patients	nan	UNKNOWN
Diabetic Cardiomyopathy and Heart Failure	nan	WITHDRAWN
Mitoquines in COPD	nan	UNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
11C-Acetate PET/CT Non-FDG-Avid Tumors	nan	UNKNOWN
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC))	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN)	nan	UNKNOWN
Dynamic Neuroimaging Biomarkers in Huntington's Disease	nan	COMPLETED
Nutritional Therapy of the Deficits of Oxidation Mitochondrial of the Fatty Acids	nan	COMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
PGC-1 and Mitochondrial Dysfunction in Diabetes	nan	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ECHS1 binder may also engage these)

Protein	Name	Similarity
P14604	—	1.000	P14604 →
Q58DM8	—	1.000	Q58DM8 →
Q5R646	—	0.999	Q5R646 →
Q8BH95	—	0.998	Q8BH95 →
P34559	—	0.969	P34559 →
ECH1	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial	0.960	landscape →
Q62651	—	0.956	Q62651 →
Q5RFG0	—	0.955	Q5RFG0 →
O35459	—	0.948	O35459 →
Q1ZXF1	—	0.939	Q1ZXF1 →
HADHA	Trifunctional enzyme subunit alpha, mitochondrial	0.927	landscape →
Q5I0K3	—	0.926	Q5I0K3 →
Q6GML7	—	0.925	Q6GML7 →
Q9VW26	—	0.923	Q9VW26 →
Q9JID6	—	0.923	Q9JID6 →
LDHA	L-lactate dehydrogenase A chain	0.923	landscape →
ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.923	landscape →
Q91WC3	—	0.922	Q91WC3 →
Q9Z1J3	—	0.922	Q9Z1J3 →
P16125	—	0.922	P16125 →
P18163	—	0.921	P18163 →
Q9W7L5	—	0.921	Q9W7L5 →
Q9PW06	—	0.921	Q9PW06 →
Q9BE24	—	0.921	Q9BE24 →
P79913	—	0.921	P79913 →
Q99P39	—	0.921	Q99P39 →
Q5ZJ60	—	0.921	Q5ZJ60 →
Q9PT42	—	0.920	Q9PT42 →
Q5RDE7	—	0.920	Q5RDE7 →
P9WNN9	—	0.920	P9WNN9 →