Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975792 | 0.91 | POLB (0.54) | POLBLMNAKMT2AMAPTMEN1 | |
| SCHEMBL4462916 | 0.91 | RXFP1 (0.47) | POLBLMNAKMT2AMAPTKDM4E | |
| SCHEMBL4972968 | 0.89 | POLB (0.50) | POLBLMNAKMT2AMAPTMEN1 | |
| SCHEMBL4974158 | 0.88 | ALDH1A1 (0.52) | POLBLMNAKMT2AMAPTMEN1 | |
| SCHEMBL4974960 | 0.87 | POLB (0.48) | POLBLMNAKMT2AMAPTMEN1 | |
| SCHEMBL3045782 | 0.86 | SMN1; SMN2 (0.51) | POLBLMNAKMT2AMAPTMEN1 | |
| SCHEMBL4977711 | 0.86 | POLB (0.47) | POLBLMNAKMT2AMAPTMEN1 | |
| SCHEMBL4453442 | 0.86 | SMN1; SMN2 (0.62) | POLBLMNAKMT2AMAPTMEN1 | |
| SCHEMBL3042993 | 0.85 | POLB (0.48) | POLBLMNAKMT2AMAPTMEN1 | |
| SCHEMBL3041004 | 0.85 | MAPT (0.48) | POLBLMNAKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | claimed |