Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4455003 | 0.74 | IGF1R (0.59) | IGF1R | |
| SCHEMBL1792487 | 0.72 | IGF1R (0.64) | IGF1RNTRK1CDK2NTRK2 | |
| SCHEMBL4923964 | 0.72 | IGF1R (1.00) | IGF1R | |
| SCHEMBL4458844 | 0.70 | IGF1R (0.54) | IGF1RNTRK1 | |
| SCHEMBL4015974 | 0.64 | IGF1R (1.00) | IGF1R | |
| SCHEMBL1792868 | 0.63 | IGF1R (0.65) | IGF1RNTRK1 | |
| SCHEMBL4099567 | 0.63 | IGF1R (0.65) | IGF1RNTRK1 | |
| SCHEMBL4468090 | 0.63 | IGF1R (1.00) | IGF1RNTRK1 | |
| SCHEMBL4467729 | 0.62 | IGF1R (0.42) | IGF1R | |
| SCHEMBL4558721 | 0.62 | IGF1R (0.78) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |