Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.31 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459152 | 0.88 | IGF1R (0.43) | IGF1RHRH3SMN1; SMN2KDM4E | |
| SCHEMBL4464502 | 0.87 | IGF1R (0.44) | IGF1RHRH3SMN1; SMN2KDM4E | |
| SCHEMBL4459206 | 0.83 | PTPN1 (0.44) | IGF1R | |
| SCHEMBL4458522 | 0.81 | IGF1R (0.45) | IGF1RHRH3SIGMAR1 | |
| SCHEMBL4466158 | 0.75 | VHL (0.34) | — | |
| SCHEMBL4471687 | 0.72 | IGF1R (0.38) | IGF1RKDM4E | |
| SCHEMBL4462239 | 0.67 | IGF1R (0.44) | IGF1R | |
| SCHEMBL1789469 | 0.62 | IGF1R (0.45) | IGF1RHRH3 | |
| SCHEMBL31010287 | 0.61 | HRH3 (0.54) | HRH3SMN1; SMN2SIGMAR1 | |
| SCHEMBL4464010 | 0.60 | IGF1R (0.40) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |