Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390141 | 0.81 | GPR119 (0.57) | GPR119PDE4BCYP2C9KCNH2 | |
| SCHEMBL386508 | 0.77 | GPR119 (0.55) | GPR119CYP2C9KCNH2 | |
| SCHEMBL390575 | 0.74 | GPR119 (0.64) | GPR119CYP2C9KCNH2 | |
| SCHEMBL388965 | 0.74 | GPR119 (0.55) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389302 | 0.72 | GPR119 (0.64) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389411 | 0.72 | GPR119 (0.66) | GPR119CYP2C9KCNH2 | |
| SCHEMBL386105 | 0.71 | GPR119 (0.67) | GPR119CYP2C9KCNH2 | |
| SCHEMBL390295 | 0.70 | GPR119 (0.77) | GPR119CYP2C9KCNH2 | |
| SCHEMBL12282975 | 0.69 | GPR119 (0.73) | GPR119PDE4BCYP2C9 | |
| SCHEMBL2553366 | 0.69 | GPR119 (0.73) | GPR119PDE4BCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1808168-B1 | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level | ARENA PHARM INC (US) | 2009-06-03 | — | — | EP | disclosed |