Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CD38 | P28907 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26921563 | 0.82 | AURKA (0.55) | AURKARPS6KB1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL2086285 | 0.81 | HTT (0.57) | AURKARPS6KB1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL20722727 | 0.80 | KDM4E (0.62) | AURKARPS6KB1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL1714828 | 0.80 | NPC1 (0.50) | AURKARPS6KB1KDM4EMEN1KMT2A | |
| SCHEMBL22261044 | 0.79 | JAK3 (0.59) | AURKARPS6KB1CD38JAK2JAK1 | |
| SCHEMBL6225105 | 0.79 | KDM4E (0.54) | AURKARPS6KB1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL5554912 | 0.79 | RPS6KB1 (0.65) | AURKARPS6KB1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL31204891 | 0.79 | RPS6KB1 (0.65) | AURKARPS6KB1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL664846 | 0.78 | AURKA (1.00) | AURKARPS6KB1AURKB | |
| SCHEMBL5261234 | 0.76 | KDR (0.62) | RPS6KB1HPGDALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291073-A1 | Compositions Comprising PKC-theta and Methods for Treating or Controlling Ophthalmic Disorders Using Same | BAUSCH & LOMB INCORPORATED | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291073-A1 | Compositions Comprising PKC-theta and Methods for Treating or Controlling Ophthalmic Disorders Using Same | PRKCQ, PRKCH, PRKCG | AURKA 2518/4885RPS6KB1 721/4885SMN1; SMN2 3351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.