Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.60 |
| ▸ | APEX1 | P27695 | 4/20 | 0.49 |
| ▸ | DUSP5 | Q16690 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10539378 | 0.88 | NR4A1 (0.57) | NR4A1APEX1DUSP5PTPN1AURKA | |
| SCHEMBL8379563 | 0.83 | NR4A1 (0.49) | NR4A1APEX1DUSP5GAAMAPT | |
| SCHEMBL156092 | 0.78 | AURKA (0.62) | NR4A1AURKAAURKBGAAALDH1A1 | |
| SCHEMBL10539390 | 0.78 | AURKA (0.62) | NR4A1AURKAAURKBGAAALDH1A1 | |
| SCHEMBL29706553 | 0.78 | AURKA (0.62) | NR4A1AURKAAURKBGAAALDH1A1 | |
| SCHEMBL10539372 | 0.77 | AURKA (0.60) | NR4A1AURKAAURKBGAAALDH1A1 | |
| SCHEMBL445795 | 0.77 | AURKA (0.60) | NR4A1AURKAAURKBGAAALDH1A1 | |
| Lithium Ion SCHEMBL20497214 | 0.76 | SLC7A11 (0.55) | NR4A1APEX1GAAMAPTPKM | |
| SCHEMBL28747694 | 0.75 | NR4A1 (0.94) | NR4A1APEX1DUSP5PTPN1AURKA | |
| Lithium Ion SCHEMBL17272354 | 0.73 | DUSP5 (0.50) | NR4A1APEX1DUSP5PTPN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8734677-B2 | Liquid-crystal coating fluid and polarizing film | NITTO DENKO CORPORATION (JP) | 2014-05-27 | — | — | US | disclosed |
| US-20120062829-A1 | LIQUID-CRYSTAL COATING FLUID AND POLARIZING FILM | NITTO DENKO CORPORATION (JP) | 2012-03-15 | — | — | US | disclosed |