Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | FASN | P49327 | 4/20 | 0.61 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8785220 | 0.89 | MAPT (0.62) | KDM4EMAPTFASNKIF11 | |
| SCHEMBL24095759 | 0.89 | PADI4 (0.55) | KDM4EMAPTFASNPADI4KIF11 | |
| SCHEMBL5330425 | 0.82 | KDM4E (0.70) | KDM4EMAPTFASNPADI4 | |
| SCHEMBL16632006 | 0.81 | KDM4E (0.49) | KDM4EMAPTFASN | |
| SCHEMBL25849956 | 0.81 | PADI4 (0.53) | KDM4EPADI4KIF11PGR | |
| SCHEMBL4455306 | 0.80 | KDM4E (0.60) | KDM4EMAPTFASN | |
| SCHEMBL15648185 | 0.79 | KDM4E (0.70) | KDM4EMAPTFASN | |
| SCHEMBL14449851 | 0.79 | KDM4E (0.70) | KDM4EMAPTFASN | |
| SCHEMBL24095589 | 0.78 | PADI4 (0.50) | KDM4EPADI4KIF11PGR | |
| SCHEMBL4465756 | 0.78 | KDM4E (0.68) | KDM4EMAPTFASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048276-A1 | Inhibitors of Fatty Acid Synthase (Fas) | MERCK SHARP & DOHME CORP. | 2009-02-19 | — | — | US | disclosed |
| US-20090048276-A1 | Inhibitors of Fatty Acid Synthase (Fas) | MERCK SHARP & DOHME CORP. | 2009-02-19 | — | — | US | disclosed |
| US-20090048276-A1 | Inhibitors of Fatty Acid Synthase (Fas) | MERCK SHARP & DOHME CORP. | 2009-02-19 | — | — | US | disclosed |
| EP-1981341-A2 | INHIBITORS OF FATTY ACID SYNTHASE (FAS) | Merck and Co., Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007089634-A2 | INHIBITORS OF FATTY ACID SYNTHASE (FAS) | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007089634-A2 | INHIBITORS OF FATTY ACID SYNTHASE (FAS) | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048276-A1 | Inhibitors of Fatty Acid Synthase (Fas) | FASN, FADS2, FADS1 | KDM4E 1768/4885MAPT 4736/4885FASN 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.