Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.74 |
| ▸ | JAK3 | P52333 | 1/20 | 0.74 |
| ▸ | IKBKB | O14920 | 2/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | PRNP | P04156 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | CHUK | O15111 | 1/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378143 | 0.90 | JAK2 (0.90) | JAK2JAK3IKBKBHDAC6HDAC1 | |
| SCHEMBL4385401 | 0.89 | JAK2 (0.76) | JAK2JAK3IKBKBHDAC6HDAC1 | |
| SCHEMBL4379852 | 0.86 | JAK2 (0.82) | JAK2JAK3IKBKBHDAC6HDAC1 | |
| SCHEMBL4377665 | 0.86 | JAK2 (0.76) | JAK2JAK3IKBKBHDAC6HDAC1 | |
| SCHEMBL13588599 | 0.85 | JAK2 (0.81) | JAK2JAK3IKBKBHDAC6HDAC1 | |
| SCHEMBL4383820 | 0.85 | JAK2 (1.00) | JAK2JAK3IKBKBHDAC6HDAC1 | |
| SCHEMBL4388808 | 0.84 | JAK2 (0.79) | JAK2JAK3IKBKBHDAC6HDAC1 | |
| SCHEMBL4376505 | 0.84 | JAK2 (0.79) | JAK2JAK3IKBKBHDAC6HDAC1 | |
| SCHEMBL7470447 | 0.84 | JAK2 (0.79) | JAK2JAK3IKBKBHDAC6HDAC1 | |
| SCHEMBL4390549 | 0.82 | JAK2 (0.76) | JAK2JAK3IKBKBHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| EP-1979329-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |