Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.79 |
| ▸ | JAK3 | P52333 | 1/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.64 |
| ▸ | PLK1 | P53350 | 1/20 | 0.63 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | PRNP | P04156 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | IKBKB | O14920 | 2/20 | 0.61 |
| ▸ | BRAF | P15056 | 1/20 | 0.60 |
| ▸ | CHUK | O15111 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | BCR | P11274 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378143 | 0.93 | JAK2 (0.90) | JAK2JAK3HDAC6HDAC1PLK1 | |
| SCHEMBL13588599 | 0.88 | JAK2 (0.81) | JAK2JAK3HDAC6HDAC1PLK1 | |
| SCHEMBL4383820 | 0.88 | JAK2 (1.00) | JAK2JAK3HDAC6HDAC1PLK1 | |
| SCHEMBL7475764 | 0.87 | JAK2 (0.71) | JAK2JAK3HDAC6HDAC1PLK1 | |
| SCHEMBL4388808 | 0.87 | JAK2 (0.79) | JAK2JAK3HDAC6HDAC1PLK1 | |
| SCHEMBL7465651 | 0.87 | ABL1 (0.76) | JAK2JAK3HDAC1PLK1IKBKB | |
| SCHEMBL4376505 | 0.87 | JAK2 (0.79) | JAK2JAK3HDAC6HDAC1PLK1 | |
| SCHEMBL4382442 | 0.85 | JAK2 (0.65) | JAK2JAK3HDAC6HDAC1PLK1 | |
| SCHEMBL4380673 | 0.85 | JAK2 (0.76) | JAK2JAK3HDAC6HDAC1PLK1 | |
| SCHEMBL4385401 | 0.85 | JAK2 (0.76) | JAK2JAK3HDAC6HDAC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |