Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | MST1R | Q04912 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | STK25 | O00506 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | MUSK | O15146 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407662 | 0.95 | MET (0.57) | METAXLFLT3 | |
| SCHEMBL19347622 | 0.91 | MET (0.51) | METKDRAXLFLT3PDGFRB | |
| SCHEMBL2328218 | 0.89 | MET (0.54) | METKDRFLT3PDGFRBKIT | |
| SCHEMBL4473446 | 0.87 | MET (0.51) | METKDRAXLFLT3FLT1 | |
| SCHEMBL3829238 | 0.87 | MET (0.52) | METKDRAXLFLT3FLT1 | |
| SCHEMBL4413202 | 0.87 | MET (0.52) | METKDRAXLFLT3KIT | |
| SCHEMBL2202519 | 0.87 | MET (0.51) | METKDRAXLFLT3FLT1 | |
| SCHEMBL3898054 | 0.86 | MET (0.50) | METKDRAXLFLT3PDGFRB | |
| SCHEMBL3831025 | 0.86 | MET (0.51) | METKDRAXLFLT3FLT1 | |
| SCHEMBL3830213 | 0.85 | MET (0.47) | METKDRMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |