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Sugi Predict / Compounds / SCHEMBL4458389

SCHEMBL4458389

SCHEMBL4458389

CCNC(Cc1cc(I)nc2ccccc12)(CC(C)(C)c1cc(F)ccc1OC)C(F)(F)F

nearest known ligand 0.51

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 19/20 0.51
▸ NR3C2 P08235 13/20 0.51
▸ PGR P06401 7/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL293125 0.86 NR3C1 (0.55) NR3C1NR3C2PGR
SCHEMBL293459 0.79 NR3C1 (0.53) NR3C1NR3C2PGR
SCHEMBL292056 0.78 NR3C1 (0.53) NR3C1NR3C2PGR
SCHEMBL292517 0.77 NR3C1 (0.53) NR3C1NR3C2PGR
SCHEMBL293411 0.76 NR3C1 (0.56) NR3C1NR3C2PGR
SCHEMBL291714 0.76 NR3C1 (0.58) NR3C1NR3C2PGR
SCHEMBL14813261 0.75 NR3C1 (0.43) NR3C1NR3C2PGR
SCHEMBL292688 0.74 NR3C1 (0.72) NR3C1NR3C2PGR
SCHEMBL291440 0.74 NR3C1 (0.72) NR3C1NR3C2PGR
SCHEMBL291365 0.74 NR3C1 (0.53) NR3C1NR3C2PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2051736-A2 COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST AND AN IMMUNOSUPPRESSIVE AGENT FOR TREATING DRY EYE Bausch & Lomb Incorporated (US) 2009-04-29 — — EP disclosed
WO-2008005686-A2 COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST AND AN IMMUNOSUPPRESSIVE AGENT FOR TREATING DRY EYE BAUSCH & LOMB INCORPORATED (US) 2008-01-10 — — WO disclosed