Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3044801 | 0.84 | LMNA (0.48) | SMN1; SMN2LMNAL3MBTL1TRPV1KMT2A | |
| SCHEMBL4973583 | 0.84 | LMNA (0.52) | SMN1; SMN2LMNAL3MBTL1TRPV1KMT2A | |
| SCHEMBL4974450 | 0.83 | TRPV1 (0.51) | SMN1; SMN2LMNAL3MBTL1TRPV1KMT2A | |
| SCHEMBL4975771 | 0.83 | LMNA (0.54) | SMN1; SMN2LMNAL3MBTL1TRPV1KMT2A | |
| SCHEMBL3038445 | 0.83 | TRPV1 (0.55) | SMN1; SMN2LMNAL3MBTL1TRPV1GAA | |
| SCHEMBL4457066 | 0.82 | LMNA (0.53) | SMN1; SMN2LMNAL3MBTL1TRPV1KMT2A | |
| SCHEMBL4976192 | 0.82 | LMNA (0.50) | SMN1; SMN2LMNAL3MBTL1TRPV1KMT2A | |
| SCHEMBL4976631 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAL3MBTL1TRPV1KMT2A | |
| SCHEMBL4975293 | 0.81 | LMNA (0.49) | SMN1; SMN2LMNAL3MBTL1TRPV1KMT2A | |
| SCHEMBL3045467 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAL3MBTL1TRPV1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | claimed |