Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 2/20 | 0.31 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.30 |
| ▸ | CDK2 | P24941 | 2/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.30 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722726 | 0.83 | MKNK1 (0.35) | HCAR2HCAR3PAK4PAK1CCNA2 | |
| SCHEMBL56939 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL17107724 | 0.62 | HCAR2 (0.48) | HCAR2HCAR3CCNA2CDK2CCNA1 | |
| SCHEMBL2745263 | 0.61 | — | — | |
| SCHEMBL4459796 | 0.60 | HCAR2 (0.35) | HCAR2HCAR3PAK4PAK1CCNA2 | |
| SCHEMBL4473245 | 0.59 | HCAR2 (0.35) | HCAR2HCAR3CCNA2CDK2CCNA1 | |
| SCHEMBL4473250 | 0.59 | HCAR2 (0.33) | HCAR2HCAR3CCNA2CDK2CCNA1 | |
| SCHEMBL21802135 | 0.58 | CYP17A1 (0.30) | — | |
| SCHEMBL1668054 | 0.57 | HCAR2 (0.52) | HCAR2HCAR3CCNA2CDK2CCNA1 | |
| SCHEMBL1667926 | 0.57 | HCAR2 (0.47) | HCAR2HCAR3CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |