Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.35 |
| ▸ | PAK4 | O96013 | 2/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473250 | 0.76 | HCAR2 (0.33) | HCAR2HCAR3CCNA2CDK2CCNA1 | |
| SCHEMBL4459321 | 0.75 | PDE8B (0.31) | — | |
| SCHEMBL31268294 | 0.75 | CCNK (0.32) | — | |
| SCHEMBL31268250 | 0.75 | IGF1R (0.34) | — | |
| SCHEMBL4472550 | 0.73 | HCAR2 (0.33) | HCAR2HCAR3 | |
| SCHEMBL31268272 | 0.73 | IGF1R (0.42) | — | |
| SCHEMBL31268293 | 0.72 | IGF1R (0.34) | — | |
| SCHEMBL31268258 | 0.69 | AURKA (0.30) | — | |
| SCHEMBL4454785 | 0.67 | — | — | |
| SCHEMBL4473245 | 0.66 | HCAR2 (0.35) | HCAR2HCAR3CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |