Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722727 | 0.83 | HCAR2 (0.42) | HCAR2HCAR3MKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL4455888 | 0.75 | HCAR2 (0.43) | HCAR2HCAR3MKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL4152477 | 0.74 | NTRK1 (0.55) | MKNK1MKNK2IGF1R | |
| SCHEMBL217487 | 0.73 | JAK2 (0.55) | — | |
| SCHEMBL4457723 | 0.72 | HCAR2 (0.43) | HCAR2HCAR3MKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL15208612 | 0.70 | NTRK1 (0.38) | MKNK1MKNK2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14723576 | 0.70 | NTRK1 (0.39) | MKNK1MKNK2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28820147 | 0.69 | HCAR2 (0.49) | HCAR2HCAR3MKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL28664537 | 0.68 | MKNK1 (0.40) | HCAR2HCAR3MKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL4696420 | 0.67 | NTRK1 (0.51) | MKNK1MKNK2CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |