Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 3/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463005 | 0.78 | HCAR2 (0.42) | HCAR2TP53MAPTDHFRPOLB | |
| SCHEMBL4458831 | 0.70 | HCAR2 (0.49) | HCAR2AURKAPDPK1TGFBR1AURKB | |
| SCHEMBL1269500 | 0.69 | — | — | |
| SCHEMBL20928952 | 0.68 | HCAR2 (0.45) | HCAR2TP53MAPTHCAR3POLB | |
| Hydrochloric Acid SCHEMBL21929877 | 0.67 | HCAR2 (0.47) | HCAR2TP53MAPTHCAR3 | |
| SCHEMBL2375615 | 0.66 | TP53 (0.63) | HCAR2TP53MAPTAURKBPOLB | |
| SCHEMBL19400917 | 0.65 | — | — | |
| SCHEMBL19806475 | 0.64 | CCR1 (0.53) | HCAR2TP53MAPTPOLBRAF1 | |
| SCHEMBL14373074 | 0.64 | SMN1; SMN2 (0.54) | HCAR2TP53MAPTPOLB | |
| SCHEMBL24120012 | 0.64 | MAPT (0.51) | HCAR2TP53MAPTHCAR3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |