Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457349 | 0.90 | MET (0.49) | METKDRAXLSRCTGFBR1 | |
| SCHEMBL377067 | 0.76 | MET (0.48) | METPDGFRAKDRFGFR2AXL | |
| SCHEMBL17370940 | 0.72 | MET (0.48) | METPDGFRAKDRFGFR2AXL | |
| SCHEMBL12444104 | 0.71 | PDGFRA (0.76) | PDGFRAKDRFGFR2 | |
| SCHEMBL5825071 | 0.70 | PDGFRA (0.59) | METPDGFRAKDRFGFR2SRC | |
| SCHEMBL4465629 | 0.69 | FGFR2 (0.68) | METPDGFRAKDRFGFR2KIT | |
| SCHEMBL31060325 | 0.68 | FGFR2 (0.78) | PDGFRAKDRFGFR2KIT | |
| SCHEMBL17117826 | 0.68 | FGFR2 (0.78) | PDGFRAKDRFGFR2KIT | |
| SCHEMBL20782678 | 0.68 | PDGFRA (0.65) | PDGFRAKDRFGFR2 | |
| SCHEMBL5824451 | 0.68 | PDGFRA (0.66) | PDGFRAKDRFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |