SCHEMBL4459263

SCHEMBL4459263

NC1=NC(N)(Cc2cccnc2)NC=C1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.40
CYP2A6 P11509 1/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2D6 P10635 1/20 0.38
ALDH1A1 P00352 1/20 0.37
PKM P14618 1/20 0.37
MMP2 P08253 1/20 0.37
HRH1 P35367 2/20 0.36
LTA4H P09960 1/20 0.36
MPO P05164 1/20 0.36
CHRNB2 P17787 2/20 0.36
CHRNA4 P43681 2/20 0.36
HRH4 Q9H3N8 2/20 0.36
HRH3 Q9Y5N1 2/20 0.36
NAPRT Q6XQN6 1/20 0.35
RECQL P46063 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29167112 0.78 CHRNA7 (0.39) CHRNA7CYP2A6CYP1A2CYP2D6ALDH1A1
SCHEMBL29167013 0.72 CHRNA7 (0.39) CHRNA7CYP2A6CYP1A2CYP2D6ALDH1A1
SCHEMBL31617173 0.70 CHRNA7 (0.39) CHRNA7CYP2A6CYP1A2CYP2D6ALDH1A1
SCHEMBL28081935 0.65 MAOA (0.50) CHRNA7CYP2A6CYP1A2CYP2D6ALDH1A1
SCHEMBL22660502 0.65 MAOA (0.46) CHRNA7CYP2A6CYP1A2CYP2D6HRH1
SCHEMBL30385240 0.65 MAOA (0.46) CHRNA7CYP2A6CYP1A2CYP2D6HRH1
SCHEMBL31617200 0.64 MAPK1 (0.37) ALDH1A1PKM
SCHEMBL9270272 0.63 KCNQ2 (0.53) CHRNA7CYP2A6CYP1A2CYP2D6LTA4H
SCHEMBL45429 0.61
Picolamine SCHEMBL17850 0.61

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009017838-A2 COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS EXELIXIS, INC. (US) 2009-02-05 WO claimed
WO-2009017838-A2 COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS EXELIXIS, INC. (US) 2009-02-05 WO disclosed