⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2471472 | 0.78 | — | — | |
| SCHEMBL2828471 | 0.78 | — | — | |
| SCHEMBL5180979 | 0.70 | — | — | |
| SCHEMBL930286 | 0.57 | — | — | |
| SCHEMBL2469876 | 0.56 | — | — | |
| SCHEMBL9487944 | 0.54 | — | — | |
| SCHEMBL27885925 | 0.53 | GABRA1 (0.33) | — | |
| SCHEMBL60696 | 0.52 | GABRA1 (0.38) | — | |
| SCHEMBL457019 | 0.51 | CYP2A6 (0.34) | — | |
| SCHEMBL4205194 | 0.51 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199510-B1 | POLYPHENYLENE ETHER RESIN COMPOSITION | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1990-09-12 | — | — | EP | claimed |
| US-7576094-B2 | Spiro derivatives as lipoxygenase inhibitors | ELI LILLY AND COMPANY (US) | 2009-08-18 | — | — | US | disclosed |
| EP-1836183-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | Galileo Pharmaceuticals, Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006065686-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | GALILEO PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | disclosed |
| US-20060128790-A1 | Spiro derivatives as lipoxygenase inhibitors | GALILEO PHARMACEUTICALS, INC. | 2006-06-15 | — | — | US | disclosed |