Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1531678 | 0.86 | TDP1 (0.56) | TDP1ALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL33928 | 0.86 | TDP1 (0.56) | TDP1ALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL1331551 | 0.86 | TDP1 (0.56) | TDP1ALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL1330911 | 0.86 | TDP1 (0.56) | TDP1ALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL33927 | 0.86 | TDP1 (0.56) | TDP1ALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL7468986 | 0.84 | TDP1 (0.54) | TDP1ALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL7073966 | 0.84 | TDP1 (0.54) | TDP1ALDH1A1LMNATSHRCYP3A4 | |
| Hydrochloric Acid SCHEMBL10445714 | 0.84 | TDP1 (0.54) | TDP1ALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL2584998 | 0.84 | TDP1 (0.54) | TDP1ALDH1A1LMNATSHRCYP3A4 | |
| Methane SCHEMBL6442579 | 0.84 | TDP1 (0.54) | TDP1ALDH1A1LMNATSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781267-A4 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | COMBINATORX INC (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1781267-A2 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | Combinatorx, Incorporated (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2005115455-A2 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | COMBINATORX, INCORPORATED (US) | 2005-12-08 | — | — | WO | disclosed |