Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | PABPC1 | P11940 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250962 | 0.82 | KMT2A (0.51) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL6644838 | 0.80 | KMT2A (0.57) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL7410653 | 0.79 | KMT2A (0.53) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL3761569 | 0.78 | KMT2A (0.68) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL6269870 | 0.78 | KMT2A (0.55) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL6640610 | 0.77 | KMT2A (0.57) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL4574251 | 0.76 | KMT2A (0.53) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| Hydrochloric Acid SCHEMBL38658753 | 0.76 | KMT2A (0.66) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL4574249 | 0.76 | KMT2A (0.56) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL50309 | 0.74 | KMT2A (0.67) | KMT2AMEN1KDM4EMAPTPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258903-A1 | Aminoethane Sulfonamide Orexin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258903-A1 | Aminoethane Sulfonamide Orexin Receptor Antagonists | HCRTR2, HCRTR1, NPSR1 | KMT2A 690/4885MEN1 2128/4885KDM4E 1285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.