Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 4/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.48 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459452 | 0.79 | KMT2A (0.57) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL3140172 | 0.79 | MAPT (0.58) | KMT2AMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9830217 | 0.78 | MAPT (0.55) | KMT2AMEN1KDM4EMAPTCXCR1 | |
| SCHEMBL6269870 | 0.78 | KMT2A (0.55) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL7886661 | 0.77 | KMT2A (0.62) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL6640610 | 0.77 | KMT2A (0.57) | KMT2AMEN1KDM4EMAPTPABPC1 | |
| SCHEMBL9829525 | 0.76 | MAPT (0.53) | KMT2AMEN1MAPTRAB9ALMNA | |
| SCHEMBL6307266 | 0.76 | CYP4F2 (0.56) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL29702259 | 0.76 | CYP4F2 (0.56) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL9829498 | 0.76 | SMN1; SMN2 (0.56) | KMT2AMEN1KDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040098-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999031061-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |