Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001467 | 1.00 | HDAC1 (0.68) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL3573257 | 0.87 | HDAC1 (0.52) | HDAC1HDAC3HDAC2HDAC10HDAC11 | |
| SCHEMBL1884523 | 0.86 | HDAC1 (0.73) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL8260193 | 0.86 | HDAC1 (0.62) | HDAC1 | |
| SCHEMBL8260177 | 0.85 | HDAC1 (0.61) | HDAC1 | |
| SCHEMBL12951208 | 0.85 | HDAC1 (0.61) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL8260582 | 0.85 | HDAC1 (0.61) | HDAC1 | |
| SCHEMBL1891537 | 0.84 | HDAC1 (0.74) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1000019 | 0.83 | HDAC1 (0.61) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1883963 | 0.81 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318541-A1 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME LLC | 2009-12-24 | — | — | US | claimed |
| US-20090318541-A1 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME LLC | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318541-A1 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | HDAC5, HAT1, BRDT | HDAC1 4/4885HDAC3 11/4885HDAC4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.